Spermidine is a natural compound in the body and everyday foods that switches on cellular cleanup, an activity that fades with age. People eating spermidine-rich diets tend to live longer with healthier hearts; animals given it live longer. It appears safe short-term, though human benefits remain promising but unproven. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | ~110–120 / 70–80 mmHg | Best-supported human signal is modest BP reduction |
| hs-CRP | <1.0 mg/L (functional <0.5) | Tracks low-grade inflammation spermidine may lower |
| LDL-C / ApoB | LDL-C <100 mg/dL; ApoB <80 mg/dL | Cardiovascular risk context |
| Fasting glucose / HbA1c | Glucose 70–90 mg/dL; HbA1c <5.4% | Metabolic effects plausible but unproven |
| eGFR | >90 mL/min/1.73m² | Kidney function for polyamine by-product clearance |
| CBC | Within lab reference range | General safety monitoring |
Cadence: Baseline, repeat at ~3 months, then every 6–12 months for ongoing use