Audit: QRS - Stinging Nettle for Health & Longevity

Audit conducted on 16/08/2026 05:07 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 83
Failed 0
N/A 10
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Protocol doses (360 mg aqueous root, 1,200 mg methanolic, 500 mg leaf t.i.d., 600 mg freeze-dried leaf) trace to ER lines 356/360/362; time-to-effect values to ER line 419; monitoring rows to ER lines 451–460; gates to ER lines 310–332.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 The ER’s “⚠️ Conflicted” flag on the urinary benefit is carried as “(conflicted)”; speculative tiers retained for the testosterone and neuroprotection claims.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Avoid-populations remain contraindications; interactions remain interactions; no tier has been shifted.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Benefits, Risks, Contraindications, Interactions and Monitoring each draw only from their corresponding ER sections.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 The QRS carries no PMIDs, author names, NCT identifiers or brand names at all.
1.6 The QRS does not introduce new attributions. 🟢 No attributions present.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Wording is lifted from or closely tracks the ER’s own register throughout.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Quantified targets and doses paired with plain-language framing in At-A-Glance.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Content is stated declaratively; no imperatives directed at an individual.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No “should”, “must” or “take” constructions in the QRS’s own voice.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 Protocol and Monitoring cells state trial-derived values rather than instructions.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the document.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms appear only where the ER’s own headings and biomarker names require them.
2.8 Information is presented in a concise and very compact manner 🟢 Tier lines are semicolon-separated fragments; gate items are stripped to the key fact.
2.9 It DOES NOT address the reader directly 🟢 Confirmed — no direct address.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Optimal functional ranges rather than conventional lab cut-offs are used throughout Monitoring.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Three-times-daily divided dosing and a ten-marker panel are presented without hedging on burden.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Monitoring cadence at 2, 4, 12 weeks then 6–12 months assumes a self-tracking reader.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 At-A-Glance closes with “a small, cheap, low-risk nudge rather than a decisive lever”, matching the ER’s calibration for this audience.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 The string “anti-aging” does not occur; the title uses “Health & Longevity”.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 Formal terms used throughout; the plainer “blood sugar”/”hay-fever” appear only in At-A-Glance, verbatim from the ER Conclusion and required there by item 7.4.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All fixed strings verified at lines 445, 490, 534, 564, 579, 608, 634, 638–640, 794 and in the tier labels of the Benefits and Risks cards.
3.2 All “” from the [qrs_template] are present in the the QRS. 🟢 Full complement present: page_title, header_topic, header_subline_date, header_subline_model, at_a_glance, action_1–3 (label/value/sub), time_1–3 (label/value/sub), benefits and risks tiers, stop_items, caution_items, marker_1–10 (name/target/why), monitoring_cadence, qualitative_item_1–7.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 The non-data-qrs-var spans (website=”evidence_review”, website=”audit”, website=”full_review”) are untouched.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section drawn on by the QRS is empty.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 Protocol labels “Root extract for urinary symptoms”, “Leaf extract for metabolic markers” and “Leaf for allergic symptoms” match the ER bold labels at lines 356, 362 and 360 verbatim.
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Monitoring marker names are verbatim ER table entries; time-to-effect labels are the minimal captions required by the template, as the ER groups all three under one “Time to effect” bullet.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji present; the ER’s tier emoji and the “⚠️” conflict marker were dropped in favour of bold tier labels and CSS.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed against the ER: benefit and risk tiers collapse to single semicolon-separated lines, gate items are stripped to the key fact, and no section carries ER narrative.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Lines 2–14; the comment opens immediately after the doctype on line 1.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening “—” at line 3, closing “—” at line 13, with the “QRS — Metadata” caption preceding it.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment; none of the values are echoed except the creation date and model, which are separate header variables.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, correctly so because the value contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: stinging_nettle_2026-0825-0314_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.7.02, matching the version badge in QRS.md.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0816-0450.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version, no qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9 matches the file on disk: stinging_nettle_2026-0825-0314_Opus_QRS.html.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all eleven keys; no stray whitespace or unnecessary quoting.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: “Stinging Nettle for Health & Longevity - Quick Reference Sheet”.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: “Stinging Nettle for Health & Longevity”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: “08/16/2026”, matching qrs_creation_date 2026-0816-0450.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: “Opus 5”.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header contains only the title and the template subline; no alternate-names line despite the ER carrying nine.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Every clause maps to the ER Conclusion at lines 492–498.
7.2 [at_a_glance] is no longer than 60 words 🟢 59 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Three-products framing (ER 492), best-supported glycemic effect (ER 494), untested testosterone claim (ER 494), “small, cheap, low-risk nudge” (ER 498).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; “hay-fever symptoms” and “blood sugar” are used in place of allergic rhinitis and fasting glucose.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No trial names, years, sample sizes or p-values.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 The glycemic effect is described only as “a modest drop”; no numeric values.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All five items come from the ER’s “Populations who should avoid Stinging Nettle” list at lines 328–332.
8.2 [stop_items] represent the Contraindications from the ER 🟢 All five ER avoid-populations are represented, none added.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Lines 567–574: five discrete <li> elements inside the span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s trailing rationales (“— nettle has documented uterine-stimulant use…”, “, given the reported galactorrhea signal…”, “, where added diuresis…”, “, where self-treating symptoms…”) are all stripped.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “(New York Heart Association Class III–IV)”, “(eGFR below 30 mL/min/1.73 m²)” and “above 100 mL” all retained; only the ER’s inline eGFR gloss was trimmed.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The ER names five avoid-populations, and the section is correspondingly populated.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eight items come from the ER bullets at lines 310–324.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 All eight ER interaction bullets present; no overlap with the five contraindications.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Lines 582–598: eight discrete <li> elements.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 The ER’s action advice (“Check glucose more frequently…”, “monitor standing blood pressure instead”, “Lithium levels should be checked…”) and mechanistic rationale are all stripped.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 Every named drug list is retained: metformin/glipizide/glimepiride/insulin; lisinopril/amlodipine/losartan; furosemide/hydrochlorothiazide; ibuprofen/naproxen; cetirizine/loratadine; berberine/chromium/alpha-lipoic acid/cinnamon; beetroot/hibiscus/garlic/magnesium; fish oil/vitamin E; saw palmetto/beta-sitosterol/pygeum.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER uses no ranking notation inside parentheses in this section.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The ER names eight interaction classes, and the section is correspondingly populated.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 All three action cells derive from the ER Therapeutic Protocol bullets at lines 356, 360 and 362.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 The three dosing regimens — root for urinary symptoms, leaf extract for metabolic markers, freeze-dried leaf for allergic symptoms — are the only bullets in the ER carrying an executable dose.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies three or more distinct actionable aspects; all three sets are used.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 Nine of nine cells populated; values 360 mg daily, 500 mg three times daily and 600 mg daily match ER lines 356, 362 and 360.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 The ER’s “Time to effect” bullet (line 419) names exactly three windows — allergic, glycemic, urinary — and all three appear.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Ordered metabolic markers (ER High tier) → urinary symptoms (Medium) → allergic symptoms (Low).
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER mentions three distinct time-to-effect aspects; all three sets are used.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 Nine of nine cells populated; “8–12 weeks”, “24 weeks” and “1 week” with subs paraphrasing ER line 419 closely.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides time-to-effect information, so the section is correctly retained.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All ten benefit entries map to the ER headings at lines 154–214.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present at lines 536, 539, 546, 552.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-separated list of ER headings only; no Magnitude figures (18.01 mg/dL, IPSS 19.8→11.8, 5.03 mmHg) carried across.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No ER parenthetical content survives; “(conflicted)” is the plain-text replacement for the ER’s “⚠️ Conflicted” flag, required by item 4.4’s emoji ban and item 1.3’s no-strengthening rule.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four benefit tiers carry at least one ER item.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All eight risk entries map to the ER headings at lines 238–288.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present at lines 610, 613, 619, 626.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 No Magnitude data (one event per 1,514 treatment days, 17–18 mg/dL, ~5 mmHg) carried across.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 “(Hives)” and “(Unexpected Milk Production)” are correctly stripped from the ER headings at lines 238 and 260.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four risk tiers carry at least one ER item.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Marker, Target and Why columns reproduce the ER biomarker table at lines 449–460.
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All ten ER table rows present: fasting glucose, HbA1c, hs-CRP, triglycerides, blood pressure, potassium/creatinine with eGFR, PSA, testosterone/SHBG, ALT, INR.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Lines 784–788 reproduce the ER’s schedule at line 447 (2 and 4 weeks, full panel at 12 weeks, then 6–12 months; urinary score at 12 and 24 weeks).

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 Items map to the ER’s qualitative marker list at lines 464–470.
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All seven ER qualitative markers present, with the trailing “— the single most responsive endpoint” clause correctly stripped from the first.

Issues 16/08/2026 05:07

Pass rate 100.00%. No issues found.

Issues 16/08/2026 05:01

  1. 11.4 — Ungrammatical time-to-effect sub: [time_2_sub] (line 514) reads “A tendency showed at 16 weeks and clear separation at 24 weeks.”; the ER states “Urinary symptom trials showed a tendency at 16 weeks and clear separation at 24 weeks”, and removing the subject leaves “showed” without an agent.

Fixes 16/08/2026 05:01

  1. 11.4 — Ungrammatical time-to-effect sub: Rewrote [time_2_sub] from “A tendency showed at 16 weeks and clear separation at 24 weeks.” to “Trials showed a tendency at 16 weeks and clear separation at 24 weeks.”, restoring the subject the ER sentence carries.

Issues 16/08/2026 04:55

  1. 4.2 / 4.3 — Interaction label invented, not ER’s: Key Interactions item 6 (QRS line 591) reads “NSAIDs (ibuprofen, naproxen) and oral antihistamines (cetirizine, loratadine)” instead of the ER’s verbatim bold label “Over-the-counter medications:” (ER line 320); the label was replaced with wording assembled from the bullet body.

Fixes 16/08/2026 04:55

  1. 4.2 / 4.3 — Interaction label restored to ER wording: Key Interactions item 6 was changed from “NSAIDs (ibuprofen, naproxen) and oral antihistamines (cetirizine, loratadine)” to the ER’s verbatim bold label “Over-the-counter medications (NSAIDs: ibuprofen, naproxen; oral antihistamines: cetirizine, loratadine)”, keeping the named example drugs as parenthetical qualifiers.