A plant compound in wine, dates, olives, honey, whole grains, and dark berries, also sold purified. Laboratory and animal work shows it strengthens the body's protective enzymes, damps inflammation, and lowers blood pressure, blood sugar, and stored fat in rodents. Almost nothing has been measured in people who swallow it; formal safety testing covers two weeks in rodents. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Fasting glucose | 75–86 mg/dL | Primary claimed metabolic effect |
| HbA1c | 4.8–5.3% | Three-month glucose average, less noisy than single readings |
| Fasting insulin | 2–5 μIU/mL | Detects insulin resistance before glucose rises |
| HOMA-IR | Below 1.0 | Single number combining fasting glucose and insulin |
| Triglycerides | Below 80 mg/dL | The lipid fraction that fell most in animal work |
| HDL-C | Above 55 mg/dL men, above 65 women | Balances the triglyceride reading; the ratio matters more than either alone |
| LDL-C with particle number | LDL-C below 100 mg/dL, ApoB below 80 mg/dL | Catches any adverse lipid shift |
| hs-CRP | Below 0.5 mg/L | Tracks the anti-inflammatory claim |
| ALT | 10–26 U/L men, 10–19 women | Primary safety marker for the liver-cell toxicity signal |
| AST | 10–26 U/L | Pairs with ALT to separate liver from muscle origin |
| eGFR | Above 90 mL/min/1.73 m² | Conjugated metabolites clear renally |
| Ferritin | 50–150 ng/mL | Detects the theoretical iron-binding effect |
| Home systolic blood pressure | 105–120 mmHg | Direct readout of the animal blood-pressure finding |
| Adiponectin | Above 10 μg/mL | The specific hormone that rose in the rodent fat-mass study |
Cadence: Liver enzymes and kidney function at four weeks, the full panel at three months, and every six months thereafter; where glucose-lowering or pressure-lowering medication is already in use, that first interval shortens to two weeks with daily home readings.