A sulfur-containing amino acid the body makes and gets from animal foods. The most consistent human evidence shows modest improvements in blood pressure, blood-sugar control, and inflammation, with weaker signals for cholesterol, exercise, and thinking. Well tolerated. Its longevity promise rests mainly on animal studies and remains unproven in people. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Blood pressure | < 120/80 mmHg | Most reliable measurable effect |
| Fasting glucose | 70–90 mg/dL | Tracks glycemic benefit |
| HbA1c | < 5.4% | Longer-term glucose control |
| Fasting insulin | 2–6 µIU/mL | Insulin sensitivity, an early aging marker |
| Triglycerides | < 80 mg/dL | Captures lipid benefit |
| LDL cholesterol | < 100 mg/dL (context-dependent) | Cardiovascular risk |
| hs-CRP | < 1.0 mg/L | Reflects anti-inflammatory effect |
| eGFR | > 90 mL/min/1.73m² | Kidney function guides clearance and caution |
Cadence: Recheck blood pressure at 2–4 weeks; reassess metabolic panel (glucose, HbA1c, lipids, hs-CRP) at 3 months, then every 6–12 months