Theacrine for Health & Longevity - Quick Reference Sheet
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Theacrine for Health & Longevity

Created on 06/27/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 4.8 – Audit

A natural relative of caffeine used as a smoother, longer-lasting energy and focus aid. Moderate doses reliably increase felt energy, mood, and concentration and reduce fatigue, with little change in heart rate or blood pressure. Longevity benefits stay speculative, long-term safety is untested, and higher doses raise blood pressure and a stress hormone. (Full Review)

Protocol

Standard Dose
100–300 mg/day
~200 mg is the most studied single dose; branded TeaCrine form is best researched
Timing
Morning / early afternoon
Long half-life means earlier use is more conservative for sleep
Dosing Schedule
Single daily dose
Long half-life (16–22 h) supports once-daily; splitting risks late-day stimulation
Time to effect
Energy & Focus
1–2 hours
Subjective energy and focus effects typically begin within 1–2 hours of an oral dose
Duration
Many hours
Long half-life means effects can persist for many hours and accumulate with daily dosing
Half-Life
16–22 hours
Far longer than caffeine; supports once-daily dosing

Benefits

Contraindications
  • Pregnancy or breastfeeding
  • Children and adolescents
  • Uncontrolled hypertension
  • Cardiac arrhythmias or recent cardiovascular events
  • Anxiety disorders or insomnia
  • Significant liver disease
    •
Key Interactions
  • Caffeine (stimulants)
  • Other CNS stimulants (amphetamine/dextroamphetamine, methylphenidate, pseudoephedrine)
  • Antihypertensive medications (lisinopril, amlodipine)
  • Over-the-counter stimulant/energy products
  • Supplement interactions (synephrine, yohimbine, methylliberine, high-dose green tea extract)
  • MAO inhibitors and serotonergic/dopaminergic agents
    •

Risk & Side Effects

  • High:
  • Medium:
  • Low: Elevated blood pressure at higher doses; stimulant-type side effects at higher doses; increased cortisol at high doses
    •
  • Speculative: Long-term and chronic-use safety; interactions with caffeine and other stimulants; pregnancy, breastfeeding, and vulnerable populations
    •

Monitoring

Marker Target Why
Resting blood pressure <120/80 mmHg Detects dose-related increases
Resting heart rate 50–70 bpm Screens for stimulant effect
Salivary or morning cortisol Within lab reference range Flags stress-axis activation

Cadence: Record baseline before starting; those with elevated blood pressure or on higher doses re-check at 1–2 weeks, then every 1–3 months while using.

Qualitative Assessment

  • Sustained energy and reduced fatigue without a sharp "crash"
  • Improved focus, motivation, and mood during the day
  • Absence of jitteriness, palpitations, or anxiety
  • No disruption to sleep onset or quality
  • Stable or unchanged blood pressure and resting heart rate
Not medical advice. Educational distillation of a single evidence review. Confirm any decision with a qualified clinician, especially in the presence of prescription drugs or chronic conditions.