Audit: QRS - Tocopherols for Health & Longevity
Audit conducted on 04/10/2026 19:47 using AI4L / Opus 5.5
Summary
| Items | Count |
|---|---|
| Total | 94 |
| Passed | 88 |
| Failed | 0 |
| N/A | 6 |
| Pass Rate | 100.00% |
- Total = Passed + Failed + N/A
- Pass Rate = Passed / (Passed + Failed) × 100
- N/A items are excluded from the pass rate calculation
1. General Rules
| # | Description | Result | Comments |
|---|---|---|---|
| 1.1 | Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. | 🟢 | All glance, protocol, time, benefit, risk, gate and monitoring content traced to ER passages (Conclusion, Therapeutic Protocol, Practical Considerations, Expected Benefits, Risks, Key Interactions, Monitoring). |
| 1.2 | Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. | 🟢 | “(theoretical)” kept on every ER-theoretical interaction and contraindication; “doses not formally compared” and “long-term outcomes remain unproven” kept. |
| 1.3 | The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). | 🟢 | No claim strengthened or softened. |
| 1.4 | The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. | 🟢 | Contraindications come from the ER avoid list, interactions from the ER interaction list, modifying factors not relabelled. |
| 1.5 | PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. | 🟢 | No PMIDs, NCT IDs, study names, experts or brands appear. |
| 1.6 | The QRS does not introduce new attributions. | 🟢 | No attributions added. |
2. Focus, Tone & Audience
| # | Description | Result | Comments |
|---|---|---|---|
| 2.1 | The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. | 🟢 | Neutral, evidence-weighted tone mirrors the ER. |
| 2.2 | The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging | 🟢 | |
| 2.3 | The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor | 🟢 | |
| 2.4 | The QRS avoids language that implies medical or clinical advice | 🟢 | |
| 2.5 | The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” | 🟢 | |
| 2.6 | The QRS never addresses “the reader” directly — it presents evidence, not guidance | 🟢 | No direct address found. |
| 2.7 | The QRS is written in plain language, avoiding unnecessary medical jargon | 🟢 | Plain language; drug classes keep ER labels with example drugs. |
| 2.8 | Information is presented in a concise and very compact manner | 🟢 | Items reduced to labels and key qualifiers. |
| 2.9 | It DOES NOT address the reader directly | 🟢 | |
| 2.10 | The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. | 🟢 | |
| 2.11 | The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. | 🟢 | |
| 2.12 | The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. | 🟢 | |
| 2.13 | Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. | 🟢 | Glance separates longevity-relevant null/harm findings from non-longevity benefits. |
| 2.14 | The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. | 🟢 | No “anti-aging” wording. |
| 2.15 | The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “oral” / “administered orally” not “taken by mouth” / “given by mouth”; “injection” not “shot”; “adverse event” not “bad reaction”). This holds on EVERY surface, including the QRS lede — the stricter plain-language bar (see 2.7) does not license lay phrasing for route of administration. Direct quotes from sources are exempt. | 🟢 | No colloquial or route-of-administration lay phrasing. |
3. Template Integrity
| # | Description | Result | Comments |
|---|---|---|---|
| 3.1 | The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” | 🟢 | All fixed headings, gate headings, tier labels and column headers unchanged from template. |
| 3.2 | All “…” from the [qrs_template] are present in the the QRS. | 🟢 | All template spans present (marker_# and qualitative_item_# expanded to 1–5). |
| 3.3 | Spans that are not addressed in a checklist item are left unchanged | 🟢 | Diff against template shows only variable content and the risks_high display:none change. |
4. Formatting
| # | Description | Result | Comments |
|---|---|---|---|
| 4.1 | When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” | 🟢 | ER Risks High is empty (“No risk reaches High”); span hidden with an HTML comment quoting the ER wording. |
| 4.2 | Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. | 🟢 | Protocol labels “Nutritional baseline”, “Fatty liver regimen”, “Best time of day” match ER bold labels. |
| 4.3 | Labels are not paraphrased, abbreviated, or invented. | 🟢 | |
| 4.4 | The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. | 🟢 | No emoji indicators found. |
| 4.5 | The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. | 🟢 | Each section condensed to labels and key qualifiers; no section extended beyond its block. |
5. Metadata
| # | Description | Result | Comments |
|---|---|---|---|
| 5.1 | The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. | 🟢 | Metadata comment directly follows <!doctype html> (line 2). |
| 5.2 | Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. | 🟢 | |
| 5.3 | The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. | 🟢 | |
| 5.4 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | Only duration is quoted (“00:02”), which contains a colon. |
| 5.5 | The filename of the source ER is stated as “er_filename: [er_filename]” | 🟢 | |
| 5.6 | Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” | 🟢 | qrs_prompt_version: 26.10.1 |
| 5.7 | Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) | 🟢 | qrs_creation_date: 2026-1004-1903 |
| 5.8 | The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” | 🟢 | |
| 5.9 | The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) | 🟢 | Opus |
| 5.10 | The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” | 🟢 | |
| 5.11 | The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) | 🟢 | Opus 5.5 |
| 5.12 | The filename of the document is stated as “qrs_filename: [filename of this document]” | 🟢 | |
| 5.13 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 |
6. Page Title & Header
| # | Description | Result | Comments |
|---|---|---|---|
| 6.1 | [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., & for &) |
🟢 | Tocopherols for Health & Longevity - Quick Reference Sheet |
| 6.2 | [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., & for &) |
🟢 | |
| 6.3 | [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] | 🟢 | 10/04/2026 |
| 6.4 | [header_subline_model] is set to [qrs_creator_ai_fullname] | 🟢 | Opus 5.5 |
| 6.5 | No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. | 🟢 |
7. At-A-Glance Section
| # | Description | Result | Comments |
|---|---|---|---|
| 7.1 | [at_a_glance] opens by saying what the intervention is — its kind (e.g., dietary supplement, prescription medication, peptide, plant, procedure, practice) — and what it is used for, in plain language, before any verdict on the evidence | 🟢 | Opens with “Tocopherols, the vitamin E family, are taken as supplements for disease prevention.” |
| 7.2 | [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section |
🟢 | Condenses ER Conclusion paragraphs 1–2. |
| 7.3 | [at_a_glance] is no longer than 70 words | 🟢 | 70 words (script count). |
| 7.4 | Every fact in [at_a_glance] is supported by a distinct passage in the ER. | 🟢 | |
| 7.5 | It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead | 🟢 | No acronyms; “imaging-dye”, “bleeding strokes” in plain language. |
| 7.6 | It DOES NOT cite specific trials (names, years, sample sizes, p-values) | 🟢 | |
| 7.7 | It DOES NOT cite effect sizes, relative risks, or statistical results | 🟢 |
8. Contraindications
| # | Description | Result | Comments |
|---|---|---|---|
| 8.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | |
| 8.2 | [stop_items] represent the Contraindications from the ER | 🟢 | All six ER avoid-populations listed. |
| 8.3 | Individual [stop_items] are formatted as <li></li> | 🟢 | |
| 8.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | No trailing dash clauses or rationale. |
| 8.5 | Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | Dose thresholds, age, percentile, staging and upper limits preserved. |
| 8.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | 🟢 | ER uses no ranking notation. |
| 8.7 | The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. |
🟢 | Section populated; ER names populations to avoid. |
| 8.8 | If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. | N/A | Section is not empty. |
9. Key Interactions
| # | Description | Result | Comments |
|---|---|---|---|
| 9.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | |
| 9.2 | [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications | 🟢 | All ER interactions listed except radiotherapy (already a contraindication) and CYP3A4 drugs (ER: no interaction found). |
| 9.3 | Individual [caution_items] are formatted as <li></li> | 🟢 | |
| 9.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | |
| 9.5 | Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | Example drug lists and “(theoretical)” qualifiers preserved. |
| 9.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | 🟢 | ER uses no ranking notation. |
| 9.7 | The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. |
🟢 | Section populated. |
| 9.8 | If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. | N/A | Section is not empty. |
10. Protocol
| # | Description | Result | Comments |
|---|---|---|---|
| 10.1 | The section is derived from the ER Protocol section |
🟢 | |
| 10.2 | The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section |
🟢 | Nutritional baseline, fatty liver regimen, best time of day. |
| 10.3 | If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | ER provides more than three actionable aspects. |
| 10.4 | All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. |
🟢 |
11. Time to Effect
| # | Description | Result | Comments |
|---|---|---|---|
| 11.1 | The three sets of [time] items cover the three most important time-to-effect aspects from the ER | 🟢 | Menstrual pain, fatty liver, sleep quality. |
| 11.2 | The sets are picked and ordered by the magnitude of the related benefit | 🟢 | High-tier benefit first, then the two Medium-tier benefits. |
| 11.3 | If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | ER provides at least three time-to-effect aspects. |
| 11.4 | All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. | 🟢 | |
| 11.5 | If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel |
N/A | ER provides time-to-effect information. |
12. Benefits
| # | Description | Result | Comments |
|---|---|---|---|
| 12.1 | The section is derived from the ER Expected Benefits section |
🟢 | |
| 12.2 | Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] | 🟢 | |
| 12.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | ER benefit headings only. |
| 12.4 | Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheticals. |
| 12.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four benefit tiers have items. |
13. Risks
| # | Description | Result | Comments |
|---|---|---|---|
| 13.1 | The section is derived from the ER Potential Risks & Side Effects section |
🟢 | |
| 13.2 | Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] | 🟢 | |
| 13.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | ER risk headings only. |
| 13.4 | Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheticals. |
| 13.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | 🟢 | risks_high span set to display: none with ER-basis comment; no empty-state text shown. |
14. Monitoring
| # | Description | Result | Comments |
|---|---|---|---|
| 14.1 | The section is derived from the ER Monitoring section |
🟢 | |
| 14.2 | All measurable/quantifiable biomarkers from the Monitoring section are listed |
🟢 | All five ER table biomarkers listed; AST noted with ALT. |
| 14.3 | [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. |
🟢 | Cadence mirrors ER Monitoring narrative. |
15. Qualitative Assessment
| # | Description | Result | Comments |
|---|---|---|---|
| 15.1 | The section is derived from the ER Monitoring section |
🟢 | |
| 15.2 | All subjective/qualitative biomarkers from the Monitoring section are listed |
🟢 | All five ER qualitative markers listed verbatim. |
Issues 04/10/2026 19:47
Pass rate 100.00%. No issues found.
Issues 04/10/2026 19:44
- 1.3 / 7.4 — “Best-confirmed” strengthens ER claim: At a Glance (QRS line 433) states “Best-confirmed gains lie outside longevity”, while the ER Conclusion (line 532) says “best-replicated benefits” and flags the kidney benefit as Conflicted and the menstrual-pain trials as small and varied.
Fixes 04/10/2026 19:44
- 1.3 / 7.4 — At a Glance wording: Changed “Best-confirmed gains lie outside longevity” to “Best-replicated gains lie outside longevity” to match the ER Conclusion’s “best-replicated benefits” (word count stays at 70).
Issues 04/10/2026 19:39
- 7.5 — Specialist term in lede: Line 433 [at_a_glance] uses “Best-replicated gains”, a research-register term a non-specialist would not use unprompted; plain wording (e.g., “most consistently confirmed”) is required.
Fixes 04/10/2026 19:39
- 7.5 — Specialist term in lede: Replaced “Best-replicated gains” with “Best-confirmed gains” in [at_a_glance]; word count stays at 70.
Issues 04/10/2026 19:36
- 1.2 / 1.3 — Lower-dose hedge dropped: At a Glance (QRS line 433) states “Fatty-liver inflammation eases, also at lower doses” as fact, dropping the ER Conclusion’s cautious “lower doses appear to work about as well as higher ones” (ER line 532); lower-dose data cover liver enzymes only and doses were not formally compared.
Fixes 04/10/2026 19:36
- 1.2 / 1.3 — Lower-dose hedge restored: In At a Glance, changed “Fatty-liver inflammation eases, also at lower doses” to “Fatty-liver inflammation eases, lower doses appearing comparable”, restoring the ER’s tentative phrasing while keeping the lede at 70 words.
Issues 04/10/2026 19:33
- 7.2 — Not execution-oriented At-a-Glance: The at_a_glance text (line 433) condenses the Conclusion’s verdicts but omits its only execution-relevant point, that in fatty liver “lower doses appear to work about as well as higher ones” (ER line 532).
Fixes 04/10/2026 19:33
- 7.2 — Dose point added to lede: Changed “Fatty-liver inflammation eases;” to “Fatty-liver inflammation eases, also at lower doses;” (ER line 532), and tightened wording elsewhere to stay within 70 words.
Issues 04/10/2026 19:30
- 1.3 — Selenium testing qualifier dropped: The Monitoring cadence (line 665) lists “selenium status for men considering 400 IU/day or more” as part of the baseline panel unconditionally, while the ER (line 494) qualifies it with “where testing is available”.
Fixes 04/10/2026 19:30
- 1.3 — Selenium testing qualifier restored: Monitoring cadence changed from “including PSA and selenium status for men considering 400 IU/day or more” to “including PSA and, where testing is available, selenium status for men considering 400 IU/day or more”, matching the ER.
Issues 04/10/2026 19:27
- 14.1 — Selenium row not from Monitoring: Monitoring row 6 “Toenail selenium” with target “At or above the 40th percentile” (QRS lines 663-669) is absent from the ER Monitoring section and biomarker table; the cut-off is taken from ER Risk-Modifying Factors and recast as a target the ER never states.
Fixes 04/10/2026 19:27
- 14.1 — Selenium row not from Monitoring: Removed Monitoring row 6 (“Toenail selenium”, target “At or above the 40th percentile”); selenium status remains only in the cadence line, as stated in the ER Monitoring section.
Issues 04/10/2026 19:25
- 1.1 — INR target misstated for warfarin users: The Monitoring INR row (line 644/647) pairs the target “0.8–1.2” with “Safety check for warfarin users”, while the ER states warfarin users “follow their prescriber’s target”.
- 2.15 — Colloquial phrase in lede: At a Glance (line 433) says “in weak kidneys” in the document’s own voice instead of the ER’s formal “impaired kidneys”.
Fixes 04/10/2026 19:25
- 1.1 — INR target for warfarin users: Changed the INR Target from “0.8–1.2” to “Prescriber’s target (reference range 0.8–1.2)”, matching the ER note that warfarin users follow their prescriber’s target.
- 2.15 — Formal kidney wording in lede: Replaced “in weak kidneys” with “in impaired kidneys” in At a Glance (word count unchanged at 70).
Issues 04/10/2026 19:21
- 1.3 — Null finding broadened to family: At a Glance (QRS line 433) says “Large trials did not lower heart disease, cancer or death” for tocopherols as a whole, while the ER Conclusion (line 530) limits this to trials “of the single form in most supplements”.
Fixes 04/10/2026 19:21
- 1.3 — Null finding scoped to form: Changed “Large trials did not lower heart disease, cancer or death” to “Large trials of the common supplement form did not lower…”, matching the ER’s “single form in most supplements”; trimmed “dietary”, “also”, “liver”, “in people” and reworded the kidney phrase to “in weak kidneys” to stay within 70 words.
Issues 04/10/2026 19:16
- 14.2 — Selenium and AST markers missing: The ER Monitoring section names selenium status as a baseline measure for men considering 400 IU/day or more (ER line 494) and pairs ALT with AST (ER line 502), but the QRS Monitoring table (QRS lines 597-662) lists neither.
Fixes 04/10/2026 19:16
- 14.2 — Selenium and AST markers added: Added a Monitoring row for toenail selenium (target at or above the 40th percentile; baseline for men considering 400 IU/day or more), noted AST alongside ALT in the ALT row, and added baseline PSA and selenium status to the cadence.
Issues 04/10/2026 19:13
- 2.15 — Colloquial “weak kidneys” phrasing: At-a-Glance (line 433) says “fewer imaging-dye kidney injuries in weak kidneys”, consumer-grade wording instead of formal terminology such as “reduced kidney function”.
- 9.2 — Anticoagulant/antiplatelet interactions missing: The ER interactions for vitamin K antagonists, antiplatelet drugs and direct oral anticoagulants (ER lines 384–386) are absent from [caution_items]; the contraindication only covers these users at doses near or above the upper limit.
Fixes 04/10/2026 19:13
- 2.15 — Colloquial “weak kidneys” phrasing: Changed “in weak kidneys” to “with reduced kidney function” in At-a-Glance and shortened “the vitamin E nutrient family” to “the vitamin E family” to stay within 70 words.
- 9.2 — Anticoagulant/antiplatelet interactions added: Added three caution items: “Vitamin K antagonists (warfarin, phenprocoumon)”, “Antiplatelet drugs (aspirin, clopidogrel, ticagrelor)” and “Direct oral anticoagulants (apixaban, rivaroxaban, dabigatran; theoretical)”.
Issues 04/10/2026 19:10
- 1.3 — Fatty-liver benefit overstated: At a Glance (line 433) groups fatty-liver inflammation under “The best-replicated gains lie outside longevity”, strengthening a Medium-tier, Conflicted benefit and omitting the ER caveat that long-term liver outcomes remain unproven (ER line 532).
Fixes 04/10/2026 19:10
- 1.3 — Fatty-liver benefit overstated: Moved fatty-liver inflammation out of the “best-replicated gains” sentence into its own sentence, “Fatty-liver inflammation also eases; long-term liver outcomes remain unproven.”, restoring the ER caveat; trimmed other wording to keep At a Glance at 70 words.
Issues 04/10/2026 19:09
- 1.3 — “Best-proven” strengthens ER claim: At a Glance (line 433) says “The best-proven gains lie outside longevity”, while the ER Conclusion says “The best-replicated benefits lie outside longevity”; the ER notes small, varied and conflicted trials, so “proven” overstates the evidence.
Fixes 04/10/2026 19:09
- 1.3 — “Best-proven” wording restored: Changed “The best-proven gains” to “The best-replicated gains” in At a Glance, matching the ER Conclusion wording (word count unchanged at 70).
Issues 04/10/2026 19:05
- 7.5 — Research jargon in lede: At a Glance (line 433) uses “best-replicated”, a research-register term a non-specialist would not use unprompted; a plain-language equivalent is needed.
Fixes 04/10/2026 19:05
- 7.5 — Research jargon in lede: Replaced “best-replicated” with the plain-language “best-proven” in At a Glance, keeping the text at 70 words.