Tributyrin is a natural butter fat that delivers butyrate, a beneficial fatty acid, to the gut in a slower, steadier, sodium-free way than butyrate salts, while shifting gut bacteria toward a healthier balance. Broader benefits for inflammation, metabolism, the brain, and longevity remain unproven in people. Low-risk and well-tolerated; best alongside a fiber-rich diet. (Full Review)
| Marker | Target | Why |
|---|---|---|
| hs-CRP | < 0.5 mg/L | Tracks systemic inflammation, a proposed tributyrin target |
| Fasting glucose | 75–90 mg/dL | Baseline glucose control |
| HbA1c | < 5.4% | Average blood sugar over ~3 months |
| Fasting insulin / HOMA-IR | Insulin 2–5 µIU/mL; HOMA-IR < 1.5 | Insulin sensitivity |
| Triglycerides | < 80 mg/dL | Metabolic and lipid status |
| Fecal calprotectin | < 50 µg/g | Gut mucosal inflammation |
Cadence: Baseline, then 4–8 weeks after starting, then every 6–12 months if used long-term