Audit: QRS - Vinpocetine for Health & Longevity
Audit conducted on 13/09/2026 10:17 using AI4L / Opus 5
Summary
| Items | Count |
|---|---|
| Total | 93 |
| Passed | 83 |
| Failed | 0 |
| N/A | 10 |
| Pass Rate | 100.00% |
- Total = Passed + Failed + N/A
- Pass Rate = Passed / (Passed + Failed) × 100
- N/A items are excluded from the pass rate calculation
1. General Rules
| # | Description | Result | Comments |
|---|---|---|---|
| 1.1 | Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. | 🟢 | Every populated span traces to ER text: protocol cells to the Therapeutic Protocol bullets, time cells to the Time to effect bullet in Practical Considerations, benefit/risk tiers to the Expected Benefits and Potential Risks & Side Effects headings, gates to Key Interactions & Contraindications, and the nine markers plus cadence to Monitoring Protocol & Defining Success. |
| 1.2 | Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. | 🟢 | No ER hedge is dropped or hardened; the animal-only reproductive finding stays “Animal pregnancy loss” in [at_a_glance] and sits in the Speculative risk tier, matching the ER. |
| 1.3 | The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). | 🟢 | The eight ER “Populations who should avoid Vinpocetine” bullets are carried as Contraindications, not downgraded to cautions; warfarin stays a contraindication and is correctly removed from the anticoagulant and CYP2C9 interaction example lists. |
| 1.4 | The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. | 🟢 | Nothing from Benefit-Modifying Factors, Risk-Modifying Factors, Risk Mitigation Strategies or Emerging Research is surfaced in the gates; the gates draw only on Key Interactions & Contraindications. |
| 1.5 | PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. | 🟢 | The QRS carries no PMIDs, citations, expert names, NCT identifiers or brand names anywhere. |
| 1.6 | The QRS does not introduce new attributions. | 🟢 | No attributions are present beyond the fixed template AI4L link and the source-ER subline. |
2. Focus, Tone & Audience
| # | Description | Result | Comments |
|---|---|---|---|
| 2.1 | The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. | 🟢 | Matches the ER’s measured, evidence-weighted register, including its even-handed treatment of the split cognitive evidence and the under-dosing hypothesis. |
| 2.2 | The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging | 🟢 | Technical precision in the gates and monitoring table sits alongside plain-language framing in [at_a_glance] and the qualitative items. |
| 2.3 | The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor | 🟢 | Content is stated as what the evidence and protocols show, not as instructions issued to an individual. |
| 2.4 | The QRS avoids language that implies medical or clinical advice | 🟢 | No imperatives or advisory verbs; [monitoring_cadence] describes the ER’s monitoring schedule rather than directing the reader. |
| 2.5 | The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” | 🟢 | No instance of “recommend”, “advise”, “should” or “must” in the document’s own voice. |
| 2.6 | The QRS never addresses “the reader” directly — it presents evidence, not guidance | 🟢 | No second-person pronouns anywhere in the rendered content. |
| 2.7 | The QRS is written in plain language, avoiding unnecessary medical jargon | 🟢 | Retained ER glosses where space allowed (“Alanine aminotransferase (a liver enzyme)”, “Montreal Cognitive Assessment (a 30-point cognitive screen)”, “human chorionic gonadotropin (the pregnancy hormone)”); remaining technical terms are the ER’s verbatim bold labels required by 4.2/9.4. |
| 2.8 | Information is presented in a concise and very compact manner | 🟢 | Tier lists are semicolon-joined single-line entries and gate items are stripped to the key fact. |
| 2.9 | It DOES NOT address the reader directly | 🟢 | Confirmed: no direct address in any span. |
| 2.10 | The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. | 🟢 | Content assumes a self-directed user, e.g. the supplement-content risk carried at Medium and the reproductive gating test in the monitoring table. |
| 2.11 | The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Three-times-daily dosing with meals, a nine-marker baseline panel and six qualitative trackers all presume a willing, effortful audience. |
| 2.12 | The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. | 🟢 | Density of the monitoring panel and the twelve-item interaction gate exceed general-population framing. |
| 2.13 | Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. | 🟢 | [at_a_glance] foregrounds the two facts that matter most to a self-directed user — that ordinary doses may be too low, and that product content is unreliable. |
| 2.14 | The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. | 🟢 | The string “anti-aging” does not occur; the header uses the ER’s canonical “Health & Longevity”. |
| 2.15 | The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “oral” / “administered orally” not “taken by mouth” / “given by mouth”; “injection” not “shot”; “adverse event” not “bad reaction”). This holds on EVERY surface, including the QRS lede — the stricter plain-language bar (see 2.7) does not license lay phrasing for route of administration. Direct quotes from sources are exempt. | 🟢 | Route of administration is given formally (“Standard oral regimen”, “intravenous doses”); no “pill”, “taken by mouth”, “shot” or “bad reaction” appears, including in the lede. |
3. Template Integrity
| # | Description | Result | Comments |
|---|---|---|---|
| 3.1 | The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” | 🟢 | All fixed strings verified byte-for-byte against the template at lines 445, 489, 533, 565, 585, 609, 638, 642-644 and 804, with the eight tier labels intact at lines 536, 540, 546, 554, 612, 616, 622 and 629. |
| 3.2 | All “<span data-qrs-var=”NAME”>…</span>” from the [qrs_template] are present in the the QRS. | 🟢 | The template’s 38 span occurrences map to the QRS’s 67 once marker_#_* expands to nine rows (27) and qualitative_item_# to six; no template span name is missing. |
| 3.3 | Spans that are not addressed in a checklist item are left unchanged | 🟢 | Template lines 12-409 (head, CSS, override link) are byte-identical to QRS lines 15-412 apart from the <title>; the three non-variable website="evidence_review", website="audit" and website="full_review" spans and the footer disclaimer are unchanged. |
4. Formatting
| # | Description | Result | Comments |
|---|---|---|---|
| 4.1 | When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” | N/A | No source ER section drawn on by the QRS is empty. |
| 4.2 | Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. | 🟢 | “Standard oral regimen”, “Split dosing rather than a single dose” and “Best time of day” are the ER’s bold labels verbatim; all twelve interaction labels likewise (“Anticoagulants”, “P-glycoprotein substrates”, “QT-prolonging medicines”, etc.). |
| 4.3 | Labels are not paraphrased, abbreviated, or invented. | 🟢 | Time-to-effect labels are lifted from the ER’s own wording inside the Time to effect bullet (“Cognitive and functional change”, “perfusion and rheological changes”, “the hearing study”); marker names match the ER biomarker table. |
| 4.4 | The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. | 🟢 | No emoji code point occurs anywhere in the file; the ER’s “⚠️ Conflicted” markers on two headings were correctly dropped. |
| 4.5 | The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. | 🟢 | Condensation was applied throughout: the ER biomarker table’s fourth “Context/Notes” column is dropped, every interaction’s “caution;”/”Mitigation:” clause is stripped, example drug lists are trimmed to three, and parenthetical glosses are shortened; residual length is driven by the completeness mandates of 9.2, 13.3, 14.2 and 15.2. |
5. Metadata
| # | Description | Result | Comments |
|---|---|---|---|
| 5.1 | The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. | 🟢 | Lines 2-14 form one HTML comment immediately after the doctype at line 1, ahead of the template banner comment at line 16. |
| 5.2 | Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. | 🟢 | Opening --- at line 3 and closing --- at line 13; the preceding “QRS — Metadata (invisible, parsed by audit tooling)” text sits outside the block. |
| 5.3 | The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. | 🟢 | Enclosed in an HTML comment and not duplicated in the header, footer or any span. |
| 5.4 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | All nine values are trimmed and unquoted except duration: "00:03", which contains a colon and therefore requires quoting. |
| 5.5 | The filename of the source ER is stated as “er_filename: [er_filename]” | 🟢 | Line 4: er_filename: vinpocetine_2026-0913-0716_Opus_ER.md, matching the ER’s own filename frontmatter value. |
| 5.6 | Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” | 🟢 | Line 5: qrs_prompt_version: 26.9.11, matching the QRS.md version badge. |
| 5.7 | Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) | 🟢 | Line 6: qrs_creation_date: 2026-0913-1009, in the required format. |
| 5.8 | The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” | 🟢 | Line 7: qrs_creator_ai_nickname: Opus. |
| 5.9 | The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) | 🟢 | “Opus” is a single word carrying no version or qualifier. |
| 5.10 | The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” | 🟢 | Line 8: qrs_creator_ai_fullname: Opus 5. |
| 5.11 | The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) | 🟢 | “Opus 5” is nickname plus version number with no context-window or other qualifier appended. |
| 5.12 | The filename of the document is stated as “qrs_filename: [filename of this document]” | 🟢 | Line 9: qrs_filename: vinpocetine_2026-0913-0716_Opus_QRS.html, matching the file on disk. |
| 5.13 | All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. | 🟢 | Re-verified across all nine keys; only the colon-bearing duration is quoted. |
6. Page Title & Header
| # | Description | Result | Comments |
|---|---|---|---|
| 6.1 | [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., & for &) |
🟢 | Line 22: “Vinpocetine for Health & Longevity - Quick Reference Sheet”, matching the ER’s canonical_topic with the ampersand entity-encoded. |
| 6.2 | [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., & for &) |
🟢 | Line 417: “Vinpocetine for Health & Longevity”. |
| 6.3 | [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] | 🟢 | Line 421 shows 09/13/2026, the correct MM/DD/YYYY rendering of qrs_creation_date: 2026-0913-1009. |
| 6.4 | [header_subline_model] is set to [qrs_creator_ai_fullname] | 🟢 | Line 425: “Opus 5”, matching the frontmatter value. |
| 6.5 | No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. | 🟢 | The header block (lines 415-428) carries only the title and the template’s fixed subline; the ER’s “Also known as” list is not reproduced. |
7. At-A-Glance Section
| # | Description | Result | Comments |
|---|---|---|---|
| 7.1 | [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section |
🟢 | Four sentences covering mechanism, the strongest signal, the contested cognitive claim with the under-dosing caveat, and the two decisive hazards — the decision-relevant core of the ER Conclusion. |
| 7.2 | [at_a_glance] is no longer than 60 words | 🟢 | 57 words. |
| 7.3 | Every fact in [at_a_glance] is supported by a distinct passage in the ER. | 🟢 | Each clause maps to the ER Conclusion paragraphs at lines 507 and 509: the vasodilator/anti-inflammatory mechanism, the disability-not-mortality signal, the split memory evidence with ordinary doses possibly too low, and the animal reproductive plus product-content concerns. |
| 7.4 | It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead | 🟢 | No acronyms; “stroke”, “brain blood vessels”, “pregnancy loss” and “product content” are all ordinary usage, and the ER’s clinical classifiers (“acute ischemic”, “embryo-fetal”) are avoided here. |
| 7.5 | It DOES NOT cite specific trials (names, years, sample sizes, p-values) | 🟢 | No trial name, year, sample size or p-value appears. |
| 7.6 | It DOES NOT cite effect sizes, relative risks, or statistical results | 🟢 | The ER’s relative risks (0.80, 0.67) and confidence intervals are absent; the signal is described qualitatively. |
8. Contraindications
| # | Description | Result | Comments |
|---|---|---|---|
| 8.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | All eight items come from that section’s “Populations who should avoid Vinpocetine” list at ER lines 352-359. |
| 8.2 | [stop_items] represent the Contraindications from the ER | 🟢 | All eight ER bullets are present, in ER order, with none added or omitted. |
| 8.3 | Individual [stop_items] are formatted as <li></li> | 🟢 | Eight <li> elements inside the [stop_items] span; HTML parses balanced. |
| 8.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | Trailing rationale stripped throughout: “Breastfeeding, for which no safety or transfer data exist” → “Breastfeeding”; the demyelinating item drops “, given the myelin-repair signal in cell work”. |
| 8.5 | Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | “Child-Pugh Class C”, “<90 days”, “platelet count below 50 × 10⁹/L”, “resting systolic blood pressure below 100 mmHg” and “in a remission phase” all retained; only the ER’s explanatory glosses inside the parentheses were trimmed. |
| 8.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | N/A | The ER’s contraindication bullets contain no ranking notation; the only symbols are absolute thresholds (“<90 days”, “below 50 × 10⁹/L”) that are self-interpreting. |
| 8.7 | The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. |
🟢 | The ER does identify such populations and the section is correctly populated rather than left empty. |
| 8.8 | If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. <!– empty: ER names no population that should avoid the intervention –> | N/A | The section is not empty. |
9. Key Interactions
| # | Description | Result | Comments |
|---|---|---|---|
| 9.1 | The section is derived from the ER Key Interactions & Contraindications section |
🟢 | All twelve items come from the bulleted interaction list at ER lines 326-348. |
| 9.2 | [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications | 🟢 | All twelve ER interaction bullets are represented; warfarin is correctly withheld from the anticoagulant and CYP2C9 example lists because it is carried as a contraindication. |
| 9.3 | Individual [caution_items] are formatted as <li></li> | 🟢 | Twelve <li> elements inside the [caution_items] span; HTML parses balanced. |
| 9.4 | Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. | 🟢 | Every “caution;”/”monitor;” rationale and every “Mitigation:” clause is stripped; each item is reduced to the drug-class label plus its parenthetical examples. |
| 9.5 | Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). | 🟢 | Every item keeps a parenthetical example list; longer lists were trimmed to three representatives (dipyridamole, fexofenadine, hydrochlorothiazide, domperidone, nattokinase, hibiscus dropped) but none was dropped entirely. |
| 9.6 | When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. | N/A | The ER’s interaction parentheses contain plain comma-separated drug names only, with no ranking notation. |
| 9.7 | The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. |
🟢 | The ER identifies twelve such entries and the section is correctly populated. |
| 9.8 | If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. <!– empty: ER names no interaction that changes how the intervention is used –> | N/A | The section is not empty. |
10. Protocol
| # | Description | Result | Comments |
|---|---|---|---|
| 10.1 | The section is derived from the ER Protocol section |
🟢 | All three action sets derive from the ER Therapeutic Protocol bullets at lines 383, 389 and 393. |
| 10.2 | The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section |
🟢 | Dose, dose splitting and timing are the three self-administrable levers; the remaining ER bullets are either clinician-administered (the infusion protocol), descriptive (half-life, competing approaches) or modifier notes (genetics, sex, age, baseline markers). |
| 10.3 | If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | The ER Therapeutic Protocol section lists eleven bullets, so all three sets are used. |
| 10.4 | All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. |
🟢 | All nine cells carry substantive ER-derived content, e.g. action_1 “5–10 mg three times daily” with “With meals, totalling 15–30 mg/day, as used in the dementia and chronic-ischemia trials”. |
11. Time to Effect
| # | Description | Result | Comments |
|---|---|---|---|
| 11.1 | The three sets of [time] items cover the three most important time-to-effect aspects from the ER | 🟢 | The ER’s Time to effect bullet names exactly three horizons — perfusion/rheological within a single infusion or the first days, cognitive and functional at 12–16 weeks, and hearing not before six months — and all three are carried. |
| 11.2 | The sets are picked and ordered by the magnitude of the related benefit | 🟢 | time_1 “Cognitive and functional change” attaches to the High-tier benefit (reduced death or dependency after acute ischemic stroke); time_2 perfusion/rheology and time_3 hearing are both Low-tier, ordered as the ER lists them within that tier. |
| 11.3 | If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. | N/A | The ER provides three distinct time-to-effect aspects, so all three sets are used. |
| 11.4 | All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. | 🟢 | All nine cells populated, e.g. time_3 “Hearing” / “6 months” / “The hearing study saw nothing before six months.” |
| 11.5 | If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel |
N/A | The ER does provide time-to-effect information, so the section is correctly retained. |
12. Benefits
| # | Description | Result | Comments |
|---|---|---|---|
| 12.1 | The section is derived from the ER Expected Benefits section |
🟢 | All twelve benefit entries correspond one-to-one with the ER’s Expected Benefits sub-headings at lines 160-228. |
| 12.2 | Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] | 🟢 | All four spans present and populated at lines 535, 538, 544 and 552. |
| 12.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | Each entry is the ER heading alone; no Magnitude figures, evidence descriptions or mechanism text carried over. |
| 12.4 | Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheses remain in any benefit tier; the “⚠️ Conflicted” marker on the chronic-cerebrovascular cognition heading is stripped as required by 4.4 and 12.3. |
| 12.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective <SPAN> is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four benefit tiers have items in the ER, so no span needs hiding. |
13. Risks
| # | Description | Result | Comments |
|---|---|---|---|
| 13.1 | The section is derived from the ER Potential Risks & Side Effects section |
🟢 | All ten risk entries correspond one-to-one with the ER sub-headings at lines 254-306. |
| 13.2 | Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] | 🟢 | All four spans present and populated at lines 611, 614, 620 and 627. |
| 13.3 | Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. | 🟢 | Each entry is the ER heading alone; the incidence figures (headache 7.9%, diplopia 5.2%, the hundredfold content range) are correctly omitted. |
| 13.4 | Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. | 🟢 | No parentheses remain in any risk tier; the “⚠️ Conflicted” marker on the sleep-disturbance heading is stripped as required by 4.4 and 13.3. |
| 13.5 | If no items of a specific sub-section (high, medium, low, speculative) are present the respective <SPAN> is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. | N/A | All four risk tiers have items in the ER, so no span needs hiding. |
14. Monitoring
| # | Description | Result | Comments |
|---|---|---|---|
| 14.1 | The section is derived from the ER Monitoring section |
🟢 | Every row derives from the biomarker table in the ER Monitoring Protocol & Defining Success section at lines 466-476. |
| 14.2 | All measurable/quantifiable biomarkers from the Monitoring section are listed |
🟢 | All nine ER biomarkers are present in ER order with their targets intact: blood pressure, full blood count with differential, platelet count, alanine aminotransferase, creatinine with eGFR, fibrinogen, hs-CRP, Montreal Cognitive Assessment and hCG. |
| 14.3 | [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. |
🟢 | Reproduces the ER’s ongoing-monitoring paragraph (line 464) and adds the pregnancy-test timing from the hCG row’s Context/Notes; no placeholder text remains. |
15. Qualitative Assessment
| # | Description | Result | Comments |
|---|---|---|---|
| 15.1 | The section is derived from the ER Monitoring section |
🟢 | All six items come from the “Qualitative markers worth tracking alongside the laboratory set” list at ER lines 480-485. |
| 15.2 | All subjective/qualitative biomarkers from the Monitoring section are listed |
🟢 | All six ER qualitative markers are carried verbatim and in ER order, from word-finding through unexplained bruising. |
Issues 13/09/2026 10:17
Pass rate 100.00%. No issues found.