Audit: QRS - Ferulic Acid for Health & Longevity

Audit conducted on 19/09/2026 02:56 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 83
Failed 0
N/A 10
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Every protocol value, time-to-effect figure, gate item, benefit, risk, biomarker target and cadence string traces to an ER passage (ER lines 360–372, 395, 336–344, 325–334, 415–435).
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 Cautious ER framing is carried through where it survives the tier/row format, e.g. marker_10_why “Glucose claim is animal-only and unverified in people” and marker_5_target “No established target exists; track the change from the individual’s own baseline”.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 Tier placement is preserved exactly (pregnancy/breastfeeding stays a contraindication, bleeding tendency stays a risk, blood pressure and glucose stay in the Low benefit tier).
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 Contraindications come only from the ER “Populations who should avoid Ferulic Acid” list; interactions only from the ER interaction bullets; no Benefit- or Risk-Modifying Factor is surfaced as a gate.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 The QRS contains no PMIDs, author names, NCT identifiers or brand names at all.
1.6 The QRS does not introduce new attributions. 🟢 No attributions of any kind are present.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Wording is lifted from ER headings and bullets, preserving the ER’s measured, evidence-first register.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Targets and cadences give actionable, self-directed handles while the language stays neutral and non-alarmist.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Statements describe what was measured (“Measured on oral dosing in adults with raised blood lipids”) rather than issuing orders.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No imperative or prescriptive instruction to a reader; protocol cells state doses as observed practice.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No occurrence of “recommended”, “advised”, “should” directed at a reader.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronouns anywhere in the document.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Technical terms retained (Child-Pugh Class C, CYP2B6, prothrombin time) are load-bearing decision-gate and biomarker names carried verbatim from the ER; no gratuitous jargon.
2.8 Information is presented in a concise and very compact manner 🟢 Magnitudes, citations, mechanisms and rationale from the ER are all stripped; gate and tier items are single clauses.
2.9 It DOES NOT address the reader directly 🟢 Confirmed — no “you”/”your” in the file.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Ten-marker monitoring panel with optimal-functional targets and a 6/12-week cadence presumes a proactive, self-tracking reader.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 Split twice-daily oral dosing, a morning topical serum before sunscreen, and repeat lab panels are all presented without hedging on effort.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Optimal-functional ranges tighter than conventional cut-offs and a 17-item decision-gate set are not general-population content.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 At-A-Glance names the topical use as best supported and flags that lifespan and blood-sugar claims rest on animal work — the distinction that matters to this audience.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 “Longevity” appears in the title and header topic; “anti-aging” appears nowhere.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “oral” / “administered orally” not “taken by mouth” / “given by mouth”; “injection” not “shot”; “adverse event” not “bad reaction”). This holds on EVERY surface, including the QRS lede — the stricter plain-language bar (see 2.7) does not license lay phrasing for route of administration. Direct quotes from sources are exempt. 🟢 Route of administration is stated as “oral” / “topical” throughout, including in At-A-Glance (“A short oral trial…”); no “pills”, “shot” or “taken by mouth”.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified: Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”; Gate headings: “Contraindications”, “Key Interactions”; Tier labels: “High”, “Medium”, “Low”, “Speculative”; Table column headers in Monitoring: “Marker”, “Target”, “Why” 🟢 All fixed strings present verbatim (lines 445, 491, 541, 578, 592, 614, 636, 640–642, 781) and all four tier labels appear in both Benefits and Risks.
3.2 All “…” from the [qrs_template] are present in the the QRS. 🟢 All 38 template variables present; the repeated marker_#_* and qualitative_item_# placeholders are correctly expanded to marker_1–marker_10 and qualitative_item_1–6.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 A masked-variable diff against [qrs_template] shows differences only inside populated variable spans, the metadata block, the title, and the repeated monitoring/qualitative rows; CSS, structure, header wiring and footer are byte-identical.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section that feeds the QRS is empty.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 action_1/2/3_label are the ER bold labels “Standard oral dose”, “Topical approach”, “Single versus split dosing” verbatim (ER lines 360, 363, 367).
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Time-to-effect labels (“Post-procedure redness”, “Lipid and inflammatory markers”, “Oral skin-barrier measures”) and all ten marker names are ER phrases verbatim (ER lines 395, 417–426).
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji in the file; the ER’s 🟩/🟥/🟨/⭕️/⚠️ markers are all stripped and tiering is carried by <strong> labels plus CSS.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Every section is condensed against the ER budget — 459-line ER reduced to 788 rendered words, with effect sizes, confidence intervals, citations, mechanisms and mitigation clauses removed; no section carries extended prose and the A4 print CSS is intact.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Single comment at lines 2–14, immediately after <!doctype html> on line 1 and before the template comment on line 16.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- at line 3, closing --- at line 13; the “QRS — Metadata” caption precedes the opening delimiter.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment; no metadata key or value is echoed by a rendered element.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, correctly so because it contains a colon; all other values are bare and untrimmed of nothing.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: ferulic_acid_2026-0919-0003_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.9.11, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0919-0242, correct format.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” — single word, no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” — nickname plus version, no qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9: qrs_filename: ferulic_acid_2026-0919-0003_Opus_QRS.html, matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all nine keys including the tooling-added git_user and git_issue; all clean.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: “Ferulic Acid for Health & Longevity - Quick Reference Sheet”, matching ER canonical_topic with the ampersand encoded.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: “Ferulic Acid for Health & Longevity”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: “09/19/2026” from qrs_creation_date 2026-0919-0242.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: “Opus 5”.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 Header holds only the title and the template subline; the ER’s “Also known as” line and all badges are omitted.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Compresses the ER Conclusion’s two evidence bodies, the contested memory finding, the animal-only claims and the clotting harm into five clauses.
7.2 [at_a_glance] is no longer than 60 words 🟢 57 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Maps one-to-one onto ER lines 453–457 (plant compound in grain bran and coffee; best-supported topical use; short oral trial on cholesterol and inflammation; animal-only lifespan and blood-sugar claims; contested memory effect; weakened platelet clotting).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; “sun-induced redness”, “inflammation markers”, “blood clotting”, “animal work” are all lay-usable terms.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No author names, years, sample sizes or p-values.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No numbers of any kind appear in the lede.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All seven items come from the “Populations who should avoid Ferulic Acid” list at ER lines 338–344.
8.2 [stop_items] represent the Contraindications from the ER 🟢 Seven ER avoidance bullets map to seven <li> with no additions and no omissions.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Lines 581–587, each item its own <li> inside the span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Every ER trailing rationale is stripped (“given the estrogen-like animal signal…”, “until the estrogen-like signal is resolved in people”, “in whom the conjugation pathways…”); no dashes introduce trailing clauses.
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “platelet count below 50 × 10⁹/L”, “Within 7 days”, “within the past 6 months”, “Child-Pugh Class C”, “(topical use)” all retained.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER avoidance list uses no ranking notation inside parentheses.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The ER names seven avoidance populations and the section is correctly populated rather than empty.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All ten items come from the interaction bullets at ER lines 325–334.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 All ten ER interaction bullets are present and none duplicates a contraindication.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Lines 595–604, each item its own <li> inside the span.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Every ER “Caution/Monitor — …” clause and every “Mitigation: …” sentence is stripped; only the interacting class and its examples remain.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 All ER example drug lists are carried verbatim; the ARB/ACE-inhibitor bullet keeps “(losartan, valsartan, ramipril)” with only the ER’s explanatory gloss trimmed, and “Other interventions” gains “(high-intensity training, sauna)” from the ER bullet body.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER interaction bullets use no ranking notation inside parentheses.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The ER names ten interactions and the section is correctly populated rather than empty.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 All three cells derive from the ER “Therapeutic Protocol” bullets at lines 360, 363, 365 and 367.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Oral dose, topical serum and dosing schedule are the three aspects actionable for this audience; the Chinese prescription-salt and cognitive combination-product routes are correctly not surfaced as self-directed actions.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER Therapeutic Protocol lists thirteen bullets, well above three.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 All nine spans populated: “500–1,000 mg daily”, “0.5% serum”, “500 mg twice daily” with ER-sourced subs (lines 449–487).

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Post-procedure redness (7 days), lipid and inflammatory markers (6 weeks) and oral skin-barrier measures (2 weeks) are taken from the ER time-to-effect bullet at line 395; the fourth, 24-week cognitive endpoint is retained inside time_3_sub.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Order follows the ER benefit tiers: photoprotection/skin recovery (High), lipid and inflammatory markers (Medium), oral skin-barrier function (Low).
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER names four distinct time-to-effect aspects.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 All nine spans populated; the subs name the measurement setting and dose from ER lines 158, 178, 222 and 395.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER provides time-to-effect information at line 395.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 All eighteen items are the ER benefit headings from lines 154–258, with the ER’s tier assignment preserved.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present and populated (lines 543, 551, 558, 565).
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Only the ER benefit names remain; every Magnitude line, percentage, relative risk, confidence interval, citation and limitation sentence is dropped.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in any of the four benefit spans.
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four ER benefit tiers contain items.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 All six items are the ER risk headings from lines 275–311 with tiers preserved.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present and populated (lines 616, 619, 622, 625).
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Only the ER risk names remain; the 30.0%/3.3% frequencies, the 39.5% induction figure, citations and genotype detail are all dropped.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in any of the four risk spans.
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. N/A All four ER risk tiers contain items.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Table and cadence derive from the ER “Monitoring Protocol & Defining Success” section (lines 413–426).
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All ten ER biomarker rows are present with Target and Why copied verbatim from the ER’s “Optimal Functional Range” and “Why Measure It?” columns.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Line 772: “Lipid panel and inflammation marker at 6 weeks and 12 weeks; blood count and liver enzymes at 12 weeks; then all of them every 6–12 months while dosing continues.” — matching ER line 413.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 All six items come from the ER “Qualitative markers worth tracking alongside the labs” list at lines 430–435.
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 Six of six ER qualitative markers present, verbatim, in ER order.

Issues 19/09/2026 02:56

Pass rate 100.00%. No issues found.

Issues 19/09/2026 02:47

  1. 11.4 — Time-to-effect subs mismatch cells: time_3_sub (line 530) states “Cognitive test scores only at 24 weeks” beneath the label “Oral skin-barrier measures” and the value “2 weeks”, and time_1_sub (line 504) gives only the photoprotection note beneath “Post-procedure redness” / “7 days” — in both cells the supporting text describes a different endpoint than the label and value it annotates.

Fixes 19/09/2026 02:47

  1. 11.4 — Time-to-effect subs realigned: Rewrote time_1_sub to describe the 7-day laser-resurfacing finding it annotates before the photoprotection note, and time_3_sub to name the 200 mg daily oral dosing in healthy men behind the 2-week skin-barrier result before the 24-week cognitive note, so each sub matches its own label and value.