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Iberin for Health & Longevity

Created on 10/23/2026 – Quick Reference based on Evidence Review created using AI4L / Opus 5.5 – Audit

Iberin is a plant sulfur compound released when cabbage-family vegetables and horseradish are chewed or cut, of interest for long-term health because it switches on antioxidant defenses in laboratory studies. Never tested alone in people, its human evidence comes from eating these vegetables and is weak and indirect. No purified product has human safety data; iberin is best understood as one ingredient of a cabbage-family-rich diet. (Full Review)

Protocol

No established iberin dose
No human trial of purified iberin
Sold only as a research chemical; rats given up to 100 µmol/kg/day for 7 days showed no lesions
Whole-food regimen (Mithen group, Quadram Institute)
400 g/week high-glucoraphanin broccoli
About six-fold more glucoiberin than standard broccoli; for 12 weeks
Myrosinase rescue for cooked crucifers
1 g powdered brown mustard per 200 g cooked broccoli
Raised urinary sulforaphane metabolites more than four-fold; the same enzyme releases iberin from glucoiberin
Time to effect
LDL cholesterol
12 weeks
Cholesterol changes measured with high-glucoraphanin broccoli
Absorption
2.3–6.1 hours
Urinary iberin conjugates peak after broccoli

Benefits

Contraindications
  • Known allergy or hypersensitivity to Brassica vegetables
  • Pregnancy or breastfeeding, for concentrated or purified forms (no safety data)
  • Active peptic ulcer or erosive gastritis, for concentrated forms (theoretical)
  • Untreated hypothyroidism or iodine deficiency, for concentrated forms (theoretical)
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Key Interactions
  • Narrow-margin CYP-metabolized drugs (warfarin, tacrolimus, cyclosporine): Monitor (theoretical)
  • Warfarin (via vitamin K–rich foods): Monitor
  • Chemotherapy drugs (docetaxel, cisplatin): Caution (theoretical)
  • Thyroid hormone replacement (levothyroxine): Monitor (theoretical)
  • UGT1A1-cleared drugs (irinotecan): Monitor (theoretical)
  • NSAIDs (non-steroidal anti-inflammatory drugs: ibuprofen, naproxen, aspirin): Caution (theoretical)
  • Acetaminophen (paracetamol): Monitor (theoretical)
  • Other isothiocyanate supplements (sulforaphane, broccoli sprout extract): Caution (theoretical); additive
  • Selenium: Monitor (theoretical); additive
  • Antibiotics for Pseudomonas infections (meropenem, gentamicin): Monitor (theoretical); potentiating
    •

Risk & Side Effects

  • High:
  • Medium:
  • Low: Gastrointestinal upset; thyroid function interference; allergic reactions to cabbage-family foods
    •
  • Speculative: Cytotoxicity and DNA damage at high concentrations; altered drug-metabolizing enzymes
    •

Monitoring

Marker Target Why
LDL-C <100 mg/dL May fall modestly
TSH 0.4–4.0 mIU/L Safety check; a rise prompts stopping concentrated products
Free thyroxine 0.8–1.8 ng/dL Safety check; confirms thyroid hormone output
Urinary isothiocyanate metabolites No established target; track change from own baseline Confirms release and absorption

Cadence: Baseline before a concentrated product (lipid panel; TSH and free thyroxine with thyroid disease or low iodine intake), repeat at 12 weeks, then every 6–12 months while concentrated products continue; gastrointestinal symptoms tracked from the first week. Food-based intake at normal culinary amounts needs no special testing.

Qualitative Assessment

  • Gastrointestinal tolerance (nausea, bloating, stool consistency)
  • Energy levels and general well-being
  • Consistency of crucifer intake and preparation method
  • Signs of thyroid slowing (cold intolerance, fatigue, weight gain) in at-risk users
Not medical advice. Educational distillation of a single evidence review. Confirm any decision with a qualified clinician, especially in the presence of prescription drugs or chronic conditions.