Audit: QRS - Iberin for Health & Longevity

Audit conducted on 28/08/2026 15:07 using AI4L / Opus 5

Iterations

Summary

Items Count
Total 93
Passed 85
Failed 0
N/A 8
Pass Rate 100.00%
  • Total = Passed + Failed + N/A
  • Pass Rate = Passed / (Passed + Failed) × 100
  • N/A items are excluded from the pass rate calculation

1. General Rules

# Description Result Comments
1.1 Every claim, magnitude, label, recommendation, and statement in the QRS is literally supported by content in the source ER. 🟢 Every populated span traces to ER text: protocol cells to Therapeutic Protocol (ER 289-297), time cells to ER 293-295 and 338, gates to ER 245-267, benefits/risks to ER 139-227, monitoring rows to the ER biomarker table (ER 366-373), qualitative items to ER 377-381.
1.2 Where the ER uses cautious phrasing (“not formally studied”, “None documented in human trials to date”, “theoretical concern”, “data are limited”), the QRS uses the same phrasing. 🟢 [time_3_sub] carries “No clinical outcome has ever been observed, so no meaningful time-to-benefit can be stated for iberin at all” verbatim from ER 338; [at_a_glance] carries “Nothing has been tested against a health outcome in a person” mirroring ER 405.
1.3 The QRS never strengthens an ER claim (e.g., “not formally studied” → “not required”) or softens one (e.g., “do not use during pregnancy” → “use with caution during pregnancy”). 🟢 “Pregnant and breastfeeding women” remains in the Contraindications gate, not the Key Interactions gate; hypothyroidism, peptic ulceration and CKD keep their ER thresholds unchanged.
1.4 The QRS does not relabel an ER fact under a different decision category. A “Benefit-Modifying Factor” from ER section is not surfaced as a “Caution”; a “Risk-Modifying Factor” is not surfaced as a “Side Effect”; etc. 🟢 All eight [caution_items] come from the ER’s interaction bullets (ER 245-259) and all five [stop_items] from “Populations who should avoid Iberin” (ER 263-267); nothing is drawn from Benefit-Modifying Factors or Risk-Modifying Factors.
1.5 PubMed IDs, study citations, expert names, clinical trial identifiers (NCT*), and brand names appear in the QRS only if they appear in the source ER for the same fact. 🟢 No PMIDs, no NCT identifiers and no brand names (Avmacol/Prostaphane) appear; “Johns Hopkins” in [action_2_label] is the ER’s own bold label at ER 289.
1.6 The QRS does not introduce new attributions. 🟢 No attribution appears that is absent from the ER.

2. Focus, Tone & Audience

# Description Result Comments
2.1 The QRS follows the tone of the ER, which is determined by the ER’s own language, phrasing, and framing. 🟢 Reserved, mechanism-first, explicitly-limited framing matching the ER throughout.
2.2 The tone of the QRS is simultaneously expert, accessible, objective, and data-driven, but also empowering and encouraging 🟢 Quantified thresholds and targets throughout; the Protocol panel gives an actionable whole-food route despite the thin evidence base.
2.3 The QRS reads as a trusted, knowledgeable guide rather than a prescriptive doctor 🟢 Gate and monitoring content is stated in nominal form (“Baseline panel before starting…”), not as instructions.
2.4 The QRS avoids language that implies medical or clinical advice 🟢 No modal or imperative advisory constructions; the only “should” (line 742) is inside an ER-verbatim qualitative marker.
2.5 The QRS “presents information” instead of “providing guidance”, “recommending”, or “advising” 🟢 No occurrence of “recommend”, “advise”, “ensure”, “consult” or equivalent in document voice.
2.6 The QRS never addresses “the reader” directly — it presents evidence, not guidance 🟢 No second-person pronoun anywhere in the file.
2.7 The QRS is written in plain language, avoiding unnecessary medical jargon 🟢 Abbreviations are confined to the Monitoring marker column where they are the ER’s own row labels; contraindications spell out “thyroid-stimulating hormone” and “estimated glomerular filtration rate”.
2.8 Information is presented in a concise and very compact manner 🟢 Gate items are bare noun phrases; benefits and risks are semicolon-joined headline facts with no elaboration.
2.9 It DOES NOT address the reader directly 🟢 Confirmed; no direct address.
2.10 The target audience is health- and longevity-oriented adults who are risk-aware, proactive, and actively seeking to optimize health or apply the intervention under review. 🟢 Optimal-range targets (hs-CRP below 0.5 mg/L, ALT below 20/17 U/L) rather than conventional reference limits address the optimizing reader.
2.11 The target audience is willing to employ lifestyle and behavioral changes as well as follow protocols that may be inconvenient, costly, or require effort. 🟢 An eight-marker panel, repeat thyroid testing and 3-5 daily cruciferous servings assume a high-effort reader.
2.12 The document is NOT written for the general population, who are unwilling to employ lifestyle and behavioral changes or follow protocols that may be inconvenient, costly, or require effort. 🟢 Content is pitched well above general-population health messaging.
2.13 Framing, takeaways, and risk/benefit weighting throughout the document reflect this audience, including where an intervention’s signal for the average person differs from its signal for this audience. 🟢 The sheet foregrounds that only exposure, not benefit, is established — the distinction that matters to an early-adopter reader.
2.14 The document’s own voice frames usage in longevity terms, not “anti-aging” (e.g., “anti-aging clinics”, “anti-aging community”, “anti-aging medicine”). Proper names that contain “anti-aging” (e.g., “American Academy of Anti-Aging Medicine”) are quoted verbatim. 🟢 “anti-aging” does not occur; the title uses “Health & Longevity”.
2.15 The document’s own voice uses formal clinical and scientific terminology, not colloquial or consumer-grade language (e.g., “oral medication” not “pill(s)”; “injection” not “shot”; “adverse event” not “bad reaction”). Direct quotes from sources are exempt. 🟢 “erosive esophagitis”, “renal tubular secretion”, “isothiocyanate conjugates” and similar formal register throughout.

3. Template Integrity

# Description Result Comments
3.1 The following labels and headings on the QRS are fixed and not modified:
• Card and section headings: “Protocol”, “Time to effect”, “Benefits”, “Risk & Side Effects”, “Monitoring”, “Qualitative Assessment”
• Gate headings: “Contraindications”, “Key Interactions”
• Tier labels: “High”, “Medium”, “Low”, “Speculative”
• Table column headers in Monitoring: “Marker”, “Target”, “Why”
🟢 All headings match the template byte-for-byte (lines 444, 484, 528, 547, 561, 581, 600, 721); “Low: “ and “Speculative: “ tier labels are unmodified, and the High/Medium list items are removed only as item 12.5/13.5 requires.
3.2 All “…” from the [qrs_template] are present in the the QRS. 🟢 All 34 template variable names are present; marker_# and qualitative_item_# are expanded to the eight and five concrete instances the content requires.
3.3 Spans that are not addressed in a checklist item are left unchanged 🟢 A structural diff against the template shows no change outside the variable spans, the metadata block and the sanctioned display:none attributes.

4. Formatting

# Description Result Comments
4.1 When the source ER section is empty, the QRS uses the ER’s own empty-state phrasing verbatim. Typical phrasings are “None documented in human trials to date” and “Not formally studied” N/A No source ER section is empty; the High and Medium benefit/risk tiers carry explanatory prose rather than an empty state, and are handled under items 12.5 and 13.5.
4.2 Where the ER presents a bulleted item as “Label: content”, the QRS uses the ER’s bold label verbatim as the cell or row label. 🟢 [action_1_label] “The whole-food alternative”, [action_2_label] “The Johns Hopkins broccoli sprout approach” and [action_3_label] “Split versus single dosing” reproduce the ER bold labels at ER 291, 289 and 297 exactly; monitoring row labels reproduce the ER table’s biomarker names.
4.3 Labels are not paraphrased, abbreviated, or invented. 🟢 Protocol, monitoring and gate labels are ER text; the Time-to-Effect cell labels name the aspects the ER bullets describe, as item 11.4 provides for.
4.4 The QRS DOES NOT use emoji indicators (no 🟩, 🟥, 🟨, etc.). Color and emphasis are conveyed through CSS and bold labels. 🟢 No emoji present; the ER’s “⚠️ Conflicted” markers on the Nrf2 benefit and the thyroid risk are correctly dropped.
4.5 The QRS is designed to render on one A4 page. Any section that has more content in the ER than fits the per-section budget is condensed by the LLM, not extended onto a second page. 🟢 Content sits within the template’s per-section budget: three protocol cells, three time cells, five gate items, eight one-line interactions, single-line tier summaries, and the eight monitoring rows and five qualitative markers that items 14.2 and 15.2 mandate.

5. Metadata

# Description Result Comments
5.1 The metadata is placed inside a single HTML comment that is the first element after “<!doctype html>” and before any other comment, head, or body content. 🟢 Lines 2-14; the comment opens immediately after <!doctype html> on line 1.
5.2 Inside that HTML comment the YAML block is delimited by a line “—” opening and a line “—” closing. Text before the opening “—” is permitted but is not parsed as YAML. 🟢 Opening --- on line 3, closing --- on line 13; the descriptive text on line 2 precedes the opening delimiter.
5.3 The metadata is not visible in any rendered view of the QRS and is not surfaced by any other element on the sheet. 🟢 Enclosed in an HTML comment and not duplicated anywhere in the body.
5.4 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Only duration: "00:03" is quoted, correctly so because the value contains a colon.
5.5 The filename of the source ER is stated as “er_filename: [er_filename]” 🟢 Line 4: er_filename: iberin_2026-0828-1344_Opus_ER.md.
5.6 Version of the QRS.md file used to create the document is stated as “qrs_prompt_version: [Version of QRS.md]” 🟢 Line 5: qrs_prompt_version: 26.7.02, matching the QRS.md version badge.
5.7 Creation date and time of the document is stated as “qrs_creation_date: [YYYY-MMDD-HHMM]” (e.g., 2026-0501-1430) 🟢 Line 6: qrs_creation_date: 2026-0828-1454, correct format.
5.8 The nickname of the AI used to create the document is stated as “qrs_creator_ai_nickname: [qrs_creator_ai_nickname]” 🟢 Line 7: qrs_creator_ai_nickname: Opus.
5.9 The nickname of the AI is just a single word model name without version, etc. (e.g., Opus, Sonnet, Grok, Gemini, ChatGPT) 🟢 “Opus” is a single word with no version or qualifier.
5.10 The full name of the AI used to create the document is stated as “qrs_creator_ai_fullname: [qrs_creator_ai_fullname]” 🟢 Line 8: qrs_creator_ai_fullname: Opus 5.
5.11 The full name of the AI consists of the [qrs_creator_ai_nickname] and the model version number and no additional qualifier (e.g., Opus 4.6, Sonnet 3.2, Grok 4.5, Gemini 3.1, ChatGPT 5.4) 🟢 “Opus 5” is nickname plus version with no qualifier.
5.12 The filename of the document is stated as “qrs_filename: [filename of this document]” 🟢 Line 9: qrs_filename: iberin_2026-0828-1344_Opus_QRS.html, matching the file on disk.
5.13 All frontmatter values are trimmed: no leading or trailing whitespace, no surrounding quotes unless the value contains a colon, bracket, or leading special character that requires YAML quoting. 🟢 Re-verified across all nine keys; no stray whitespace or unnecessary quoting.

6. Page Title & Header

# Description Result Comments
6.1 [page_title] is set to the [canonical_topic] of the ER frontmatter followed by “ - Quick Reference Sheet” (e.g., “Intervention - Quick Reference Sheet”). The [canonical_topic] is HTML-entity-encoded as needed (e.g., &amp; for &) 🟢 Line 22: “Iberin for Health & Longevity - Quick Reference Sheet”, matching ER canonical_topic with the ampersand encoded.
6.2 [header_topic] is set to the [canonical_topic] of the ER frontmatter, with HTML entities encoded as needed (e.g., &amp; for &) 🟢 Line 417: “Iberin for Health & Longevity”.
6.3 [header_subline_date] is set to [qrs_creation_date reformatted as MM/DD/YYYY] 🟢 Line 421: “08/28/2026”, correctly derived from qrs_creation_date: 2026-0828-1454.
6.4 [header_subline_model] is set to [qrs_creator_ai_fullname] 🟢 Line 425: “Opus 5”.
6.5 No additional header content appears: no badge, version stamp, AKA / alternate names line, source-AI attribution, audit date, or QRS variant marker. 🟢 The header carries only the title and the template subline; the ER’s “Also known as” line is not reproduced.

7. At-A-Glance Section

# Description Result Comments
7.1 [at_a_glance] is dense, execution-oriented summary of the ER Conclusion section 🟢 Lines 433-437 condense ER 403-405 to what it is, how it acts, where the evidence comes from, and the decision-relevant fact that no human outcome has been tested.
7.2 [at_a_glance] is no longer than 60 words 🟢 56 words.
7.3 Every fact in [at_a_glance] is supported by a distinct passage in the ER. 🟢 Sentence 1 ← ER 403; sentence 2 ← ER 403; sentence 3 ← ER 405; sentence 4 ← ER 405 (“None of that has been tested against a health outcome in a person”).
7.4 It DOES NOT use acronyms or technical classifications that require specialist knowledge, uses plain-language terms instead 🟢 No acronyms; “reactive sulfur compound”, “cells in culture” and “waste-clearing programs” are the ER Conclusion’s own plain-language renderings.
7.5 It DOES NOT cite specific trials (names, years, sample sizes, p-values) 🟢 No trial name, year or sample size appears.
7.6 It DOES NOT cite effect sizes, relative risks, or statistical results 🟢 No numeric result of any kind appears.

8. Contraindications

# Description Result Comments
8.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All five items map to “Populations who should avoid Iberin” at ER 261-267.
8.2 [stop_items] represent the Contraindications from the ER 🟢 All five ER avoid-populations are represented, none omitted and none added.
8.3 Individual [stop_items] are formatted as <li></li> 🟢 Lines 550-556: five <li> elements inside the [stop_items] span.
8.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Every ER “since/for whom/because” rationale clause is stripped (e.g. ER 263 “…, since every commercial source is labelled not for human consumption…” → “Anyone considering isolated iberin from a chemical supplier”).
8.5 Parenthetical qualifiers from the ER bullet — time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 “(thyroid-stimulating hormone above 10 mIU/L)”, “below 100 µg/day”, “(Los Angeles grade C or D)” and “(estimated glomerular filtration rate below 30 mL/min/1.73 m²)” are all retained.
8.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER’s contraindication parentheticals use spelled-out comparators (“above 10 mIU/L”, “below 30 mL/min/1.73 m²”) and a named staging class; no ranking notation is used.
8.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no population, condition, or scenario for which the intervention should be avoided, deferred, or used only under specialist supervision. 🟢 The section is populated, and the ER does identify avoid-populations, so the constraint holds.
8.8 If the section is left empty, an HTML comment inside the [stop_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

9. Key Interactions

# Description Result Comments
9.1 The section is derived from the ER Key Interactions & Contraindications section 🟢 All eight items map to the ER interaction bullets at ER 245-259.
9.2 [caution_items] represent the Key Interactions from the ER, excluding any that are already listed as Contraindications 🟢 All eight ER interaction bullets are present and none duplicates a Contraindication.
9.3 Individual [caution_items] are formatted as <li></li> 🟢 Lines 564-571: eight <li> elements inside the [caution_items] span.
9.4 Items are as concise as possible. No trailing explanations, no elaborations, no mechanistic rationale, no attributions, no citations, no study details. No content after an em-dash, en-dash, or hyphen-dash (e.g., “— dose reduction required”, “— reduced efficacy”) — these trailing clauses are stripped. Just the key fact. 🟢 Severity words, mechanism, mitigation text and the Gong/Wang/Nowicki citations are all stripped; each item is the bare agent or exposure.
9.5 Parenthetical qualifiers from the ER bullet — example drug lists, time windows, severity classes, threshold values, clinical staging — ARE preserved as part of the item, kept as concise as possible (shortened or trimmed where needed to fit the one-page budget, but never dropped entirely). 🟢 All five ER example-drug lists are carried through intact: NAC/glutathione/alpha-lipoic acid; sulforaphane/erucin/alyssin/iberverin; warfarin/acenocoumarol/phenprocoumon; levothyroxine/liothyronine; omeprazole/calcium carbonate.
9.6 When the ER uses ranking notation inside parens (e.g., “>” for severity ordering) that depends on an explanatory phrase to interpret, normalize the items to a plain comma-separated list rather than carrying through the bare symbol. N/A The ER’s interaction parentheticals are plain comma-separated drug lists with no ranking notation.
9.7 The section is left empty ONLY IF the ER’s Key Interactions & Contraindications section identifies no interaction, additive effect, or exposure that changes how the intervention is used. 🟢 The section is populated, and the ER does identify interactions, so the constraint holds.
9.8 If the section is left empty, an HTML comment inside the [caution_items] span records the ER basis for the absence, naming or quoting the ER text relied on. E.g. N/A The section is not empty.

10. Protocol

# Description Result Comments
10.1 The section is derived from the ER Protocol section 🟢 All three cells derive from the ER Therapeutic Protocol bullets at ER 289, 291 and 297.
10.2 The three sets of [action] items cover the three most important actionable implementation aspects from the ER Protocol section 🟢 Dose form and amount (whole-food route), the quantified extract regimen, and dose distribution — the only three bullets in the ER Therapeutic Protocol that carry an executable instruction.
10.3 If less that three distinct actionable implementation aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies more than three actionable implementation aspects and all three sets are used.
10.4 All used [action_#label], [action#value], [action#_sub] items are filled with meaningful content derived from the ER Protocol section. 🟢 Nine of nine spans carry substantive ER-derived content; “3-5 servings daily” ← ER 291, “25-100 µmol every 8 hours” ← ER 289, “Split across meals” ← ER 293/297.

11. Time to Effect

# Description Result Comments
11.1 The three sets of [time] items cover the three most important time-to-effect aspects from the ER 🟢 Systemic exposure (ER 293/295), enzyme induction (ER 338) and clinical benefit (ER 338) are the only three time horizons the ER supplies.
11.2 The sets are picked and ordered by the magnitude of the related benefit 🟢 Correct descending order: systemic exposure is the ER’s only Low-tier (highest-rated) benefit, enzyme induction is Speculative, and clinical benefit has no tier at all.
11.3 If less that three distinct time-to-effect aspects are mentioned in the ER the unused sets are left empty and made invisible, not filled with placeholder text or empty-state phrasing. N/A The ER supplies three distinct time-to-effect aspects and all three sets are used.
11.4 All used [time_#label], [time#value], [time#_sub] items are filled with meaningful content derived from the ER. 🟢 Nine of nine spans carry ER-derived content; [time_1_sub] merges the ER’s peak-time and half-life statements, [time_2_sub] and [time_3_sub] split the ER’s “Time to effect” bullet at ER 338.
11.5 If the ER does not provide any information on time to effect, the section is removed completely from the Protocol Panel N/A The ER does provide time-to-effect information (ER 293-295, 338), so the section is correctly retained.

12. Benefits

# Description Result Comments
12.1 The section is derived from the ER Expected Benefits section 🟢 Both populated tiers map to ER 129-165.
12.2 Key variables are [benefits_high], [benefits_medium], [benefits_low], [benefits_speculative] 🟢 All four spans present at lines 530-540.
12.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Each tier is a semicolon-joined list of the ER’s benefit headings; the 19-29% urinary recovery figure, the 0.94-2.27 µmol/L plasma peak and the Ernst/Shibata/Gong/Jakobsen/Yahiya citations are all stripped.
12.4 Parenthetical content — including effect sizes, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in [benefits_low] or [benefits_speculative].
12.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 The ER records no High and no Medium benefit; lines 530-531 set both spans to style="display: none" with no empty-state text.

13. Risks

# Description Result Comments
13.1 The section is derived from the ER Potential Risks & Side Effects section 🟢 Both populated tiers map to ER 189-227.
13.2 Key variables are [risks_high], [risks_medium], [risks_low], [risks_speculative] 🟢 All four spans present at lines 583-594.
13.3 Items are as concise as possible. No explanations, no elaborations, no effect sizes, no qualifiers, no attributions, no citations, no study details, no mechanistic explanations, etc. Just the key fact. 🟢 Both tiers reduce to the ER’s risk headings; the Shapiro, Chartoumpekis, Steverding, Jakubikova and Wang citations and all magnitude prose are stripped.
13.4 Parenthetical content — including frequencies, severity grades, sample notes, mechanistic hints, and example studies — is stripped, NOT preserved. 🟢 No parentheses appear in [risks_low] or [risks_speculative].
13.5 If no items of a specific sub-section (high, medium, low, speculative) are present the respective is set to “display=none”, not filled with “None documented in human trials to date” or similar empty-state phrasing. 🟢 The ER records no High and no Medium risk; lines 583-584 set both spans to style="display: none" with no empty-state text.

14. Monitoring

# Description Result Comments
14.1 The section is derived from the ER Monitoring section 🟢 Rows map one-to-one to the ER Monitoring Protocol & Defining Success biomarker table at ER 366-373.
14.2 All measurable/quantifiable biomarkers from the Monitoring section are listed 🟢 All eight are present in ER order: TSH, Free T4, TPO antibodies, hs-CRP, GGT, ALT, eGFR, urinary isothiocyanate conjugates — with targets and rationales reproduced verbatim.
14.3 [monitoring_cadence] is populated with the monitoring cadence/frequency derived from the ER Monitoring section. It is not left with placeholder text or empty. 🟢 Lines 712-715 reproduce the ER’s schedule at ER 362 and 368: baseline panel, thyroid at 12 weeks then 6 and 12 months, other markers every 6 to 12 months, TPO once at baseline.

15. Qualitative Assessment

# Description Result Comments
15.1 The section is derived from the ER Monitoring section 🟢 All five items map to the ER’s “Qualitative markers worth tracking” list at ER 377-381.
15.2 All subjective/qualitative biomarkers from the Monitoring section are listed 🟢 All five are present verbatim and in ER order: upper GI comfort, bloating and flatulence, cold intolerance/fatigue/dry skin, energy and cognitive clarity, sleep quality.

Issues 28/08/2026 15:07

Pass rate 100.00%. No issues found.

Issues 28/08/2026 15:00

  1. 9.4 — Trailing clause after hyphen-dash: The last Key Interactions item at line 571, “Other interventions - fasting and ketogenic protocols”, carries content after a hyphen-dash, which item 9.4 requires to be stripped.

Fixes 28/08/2026 15:00

  1. 9.4 — Trailing clause after hyphen-dash: Replaced the Key Interactions item “Other interventions - fasting and ketogenic protocols” with “Fasting and ketogenic protocols”, dropping the vacuous prefix and the hyphen-dash so only the key fact remains.