Japanese knotweed is the cheapest practical source of resveratrol. Its most credible benefits are modest and centered on the heart and metabolism: better blood-vessel flexibility, lower blood pressure at higher doses, and improved blood sugar in people with diabetes. Bone and brain effects are preliminary, and longevity claims rest on animal studies. Risks are mostly mild digestive upset. (Full Review)
| Marker | Target | Why |
|---|---|---|
| Systolic/Diastolic Blood Pressure | ~110–120 / 70–78 mmHg | Primary cardiovascular response marker |
| Fasting Glucose | 75–86 mg/dL | Tracks glycemic effect, esp. in diabetics |
| HbA1c | <5.4% | Average blood sugar over ~3 months |
| hs-CRP | <1.0 mg/L | Systemic inflammation response |
| ALT / AST | <25 U/L (ALT), <25 U/L (AST) | Screens for rare emodin-related liver stress |
| Lipid Panel (LDL, HDL, triglycerides) | LDL <100, HDL >55, TG <90 mg/dL | Secondary cardiometabolic effect |
| eGFR / Creatinine | eGFR >90 mL/min/1.73m² | Safety at higher doses |
| Estradiol | Age/sex-appropriate | Context for phytoestrogen exposure |
Cadence: Recheck at 4–12 weeks after starting, then every 3–6 months on higher doses (or every 6–12 months for low-dose maintenance)